In mid-aged, it is common for the waist to become wider, both men and women. However, the reason behind this phenomenon is not yet fully clarified. Now, a new study, published on the 25th, sheds light on what causes increased abdominal fat through aging.
Published in Scientific Journal Sciencethe research was conducted by City of Hope, one of the largest cancer research and treatment organizations in the United States. According to the researchers, aging increases the production of new fat cells by the body, especially around the belly.
Discoveries can help develop new therapies to prevent abdominal sagging and prolong life expectancy.
How was the study done?
To reach the conclusions, the researchers conducted a series of mice experiments later validated in human cells. They focused on white adipose fabric, responsible for age -related weight gain.
Although it is already known that fat cells increase in size with age, scientists suspect that white adipose tissue also expands by producing new fat cells.
To test this hypothesis, the researchers focused on adipocyte progenitor cells (APCs), a group of stem cells in white adipose tissue that evolve to fat cells.
The team transplained the APCs of young and older mice to a second group of young mice. According to the researchers, APCs have generated a large amount of fat cells faster on older animals.
However, when the team transplained APCs from young mice into older mice, stem cells did not produce many new fat cells. These results confirm that older APCs are able to produce new fat cells regardless of the age of the host.
“While the growth capacity of most adult stem cells decreases with age, the opposite occurs with APCs-aging releases the power of these cells from evolving and spreading,” says Adolfo Garcia-Cana, head of the City of Hope’s Molecular and Mobile Endocrinology Department in a statement.
“This is the first evidence that our bellies expand with age due to the high production of new fat cells through APCs,” he says.
In addition, aging has also transformed APCs into a new type of stem cell, called compromised pre-adipocytes, age-specific (CP-A). These cells are already in middle age, producing new fat cells, which explains why older mice gain more weight.
A signaling pathway called leukemia inhibitory factor receptor (LIFR) proved essential to promote the multiplication and evolution of these CP-A cells in fat cells.
“We found that the body’s fat production process is driven by LIFR. While young mice do not need this signal to produce fat, older mice need,” explains Qiong (Annabel) Wang, a corresponding co -author of the study in a statement. “Our research indicates that LIFR plays a crucial role in stimulating CPs to create new fat cells and expand abdominal fat in older mice.”
After animal experiments, researchers used RNA sequencing in a single cell of people of various ages, studied the human tissue APCs in the laboratory. Again, the team also identified similar CP-A cells, which had a larger number in tissues of middle-aged people. The discovery also illustrates that CPs in humans have a high ability to create new fat cells.
“Our findings highlight the importance of controlling the formation of new fat cells to treat age -related obesity,” said Wang. “Understanding the role of CPs in metabolic disorders and how these cells arise during aging can lead to new medical solutions to reduce abdominal fat and improve health and longevity.”
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This content was originally published in why the waist increases after 45 years? New study responds on CNN Brazil.
Source: CNN Brasil
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